Abstract
Water is the most environmentally benign inexpensive solvent, and therefore aqueous mediated organic reactions constitute the ideal green chemistry. We herein report an environment friendly Diels Alder reaction of biologically active dihydropyrimidine (DHPM) as dienophile with glyoxime, dimethyl glyoxime and diaminoglyoxime as diene using water as solvent. Though the reaction was slow at room temperature, rate enhancement was observed when it was carried out at the reflux temperature. Further the reaction was also found to proceed smoothly with N-phenyl maleimide as dienophile.
Recommended Citation
Khan, Rasheeth Ahmed; Krishnamoorthy, Lakshmi; and S, Karthik
(2014),
AQUEOUS MEDIATED DIELS-ALDER REACTION: A SIMPLE ROUTE TO THE SYNTHESIS OF PIPERIZINE DERIVATIVES,
Yanbu Journal of Engineering and Science: Vol. 9:
Iss.
1, 13-19.
DOI: https://doi.org/10.53370/001c.24198
Available at:
https://yjes.researchcommons.org/yjes/vol9/iss1/2
