SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME 4-(6-METHYL-2- NAPHTHYL)-5,6-DIHYDRO-6-(SUBSTITUTED PHENYL)-4H-1,3-OXAZINE-2-AMINES

Authors

Ganesamoorthy Thirunarayanan, Annamalai University, India
Krishnamoorthy Guna Sekar, National College, IndiaFollow

Abstract

Some 4-(6-methyl-2-naphthyl)-5,6-dihydro-6-(substituted phenyl)-4H-1,3-oxazine-2- amines have been synthesised by hydroxyapatite catalyzed solvent-free cyclization of 6- methyl-2-naphthyl chalcones and urea under microwave irradiation. The yields of the oxazine were more than 85%. The synthesised oxazine amines have been characterized by their physical constants, analytical and spectroscopic data. The antimicrobial activities of all prepared 4-(6-methyl-2-naphthyl)-5, 6-dihydro-6-(substituted phenyl)-4H-1,3- oxazine-2-amines have been evaluated using Bauer-Kirby disc diffusion method with a variety of bacterial and fungal strains.

Recommended Citation

Thirunarayanan, Ganesamoorthy and Sekar, Krishnamoorthy Guna (2016), SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME 4-(6-METHYL-2- NAPHTHYL)-5,6-DIHYDRO-6-(SUBSTITUTED PHENYL)-4H-1,3-OXAZINE-2-AMINES, Yanbu Journal of Engineering and Science: Vol. 12: Iss. 1, 29-40.
DOI: https://doi.org/10.53370/001c.24311
Available at: https://yjes.researchcommons.org/yjes/vol12/iss1/4