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Abstract

A facile spectrophotometric method for the determination of mosapride is described. This method is based on the reaction of mosapride with nitrite in acid medium to form diazonium ion, which is coupled with acetylacetone or ethyl acetoacetate in basic medium to form azo dyes, which shows absorption maxima at 402

or 422 nm. The method obeys Beer’s law in the concentration range of 0.4-13.5 μgml-1 of mosapride with acetylacetone and 0.5-17.0 μgml-1 of mosapride with ethyl acetoacetate. The molar absorptivity and Sandell’s sensitivity of mosapride-acetylacetone

and mosapride-ethyl acetoacetate azo dyes are 1.026x104 lmol-1cm-1, 4.484 x 10-3 μgcm-2 and 1.097x104 lmol-1cm-1, 4.193x10-3 μgcm-2 respectively. The dye formed is stable for 8 hrs. The optimum reaction conditions and other analytical parameters are

evaluated. No interference observed from common excipients. The method has been successfully applied to the determination of mosapride in pharmaceutical samples.

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